Angiotensin and the Heart by Gerd Heusch,H. Grobecker,B.E. Strauer

By Gerd Heusch,H. Grobecker,B.E. Strauer

within the final decade, ACE inhibitors became a cornerstone of cardiovascular drug treatment. worthy results in sufferers with high blood pressure, middle failure, and put up myocardial infarction were verified in huge scientific trials. In parallel, ex perimental study has shifted the curiosity from the speedy homeostatic functionality of the circulating renin-angiotensin-system to the a number of paracrine capabilities of neighborhood tissue renin-angiotensin-systems, together with hypertrophy, hyperplasia, athe- oenesis, and vasomotion. . It was once the purpose or a symposium held in Hamburg, October 22-24, 1992, to assemble a global panel of experimental and scientific scientists and to debate the latest findings at the function of angiotensin and linked mediators in automobile diovascular edition and disorder, with a selected emphasis at the remedy of such sickness by means of ACE inhibitors. The assembly and this booklet have been generously supported via Astra chemical compounds. H. Grobecker G. Heusch B. E. Strauer Contents Foreword. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . V advent neighborhood expression and pathophysiological position of renin-angiotensin within the blood vessels and middle Dzau, V. J. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Myocardial Perfusion Angiotensin, ACE-inhibitors and endothelial keep watch over of vasomotor tone Luscher, T. F. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 neighborhood and neurohumoral keep watch over of coronary blood movement Krajcar, M., G. Heusch. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 ACE-inhibitors in coronary artery sickness? Vogt, M., W. Matz, B. E. Strauer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . forty three Myocardial Hypertrophy Molecular mechanisms of cardiac gene expression Nadal-Ginard, B., V. Mahdavi . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . sixty five Myocardial perfusion established and self reliant mechanisms of local myocardial disorder in hypertrophy Vatner, S. F., L. Hittinger . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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